منابع مشابه
KSR: A novel player in the RAS pathway
Over the past 5 years or so, developmental geneticists studying the nematode and the fruit fly have provided many new insights into the signaling pathways linking cell surface receptor tyrosine kinases with nuclear transcription factors. A central component in this information transfer mechanism is the RAS protein, a low molecular weight GTP-binding protein that is a proto-oncogene product in m...
متن کاملKSR, a novel protein kinase required for RAS signal transduction
We have identified and characterized two genes in Drosophila whose products are required for activated RAS to signal with normal efficiency, but do not appear to effect signaling by activated RAF. One encodes the beta subunit of type I geranylgeranyl transferase, a prenylation enzyme essential for targeting RAS to the plasma membrane. The other encodes a protein kinase that we have named kinase...
متن کامل[Recent progress of KSR-a MAPK scaffold of the Ras pathway.].
Kinase Suppressor of Ras (KSR) is an intriguing component of the Ras pathway that was first identified by genetic studies performed in Drosophila melanogaster and Caenorhabditis elegans. In both organisms, inactivating mutations in KSR suppress the phenotypic effects induced by activated Ras. These findings together with the fact that KSR contains many structural features characteristic of a pr...
متن کاملThe ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans
By screening for mutations that suppress the vulval defects caused by a constitutively active let-60 ras gene, we identified six loss-of-function alleles of ksr-1, a novel C. elegans gene. Our genetic analysis showed ksr-1 positively mediates Ras signaling and functions downstream of or in parallel to let-60. In the absence of ksr-1 function, normal Ras signaling is impaired only slightly, sugg...
متن کاملThe C. elegans ksr-1 gene encodes a novel raf-related kinase involved in Ras-mediated signal transduction
Vulval induction in C. elegans is controlled by a highly conserved signaling pathway similar to the RTK-Ras-MAPK cascade in mammals. By screening for suppressors of the Multivulva phenotype caused by an activated let-60 ras allele, we isolated mutations in a gene, ksr-1, that acts as a positive modifier of vulval induction and is required for at least two other let-60 ras-mediated processes. Al...
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ژورنال
عنوان ژورنال: Cell
سال: 1995
ISSN: 0092-8674
DOI: 10.1016/0092-8674(95)90198-1